Medical Science - 𝐍𝐞𝐱𝐮𝐬 𝐆𝐥𝐨𝐛𝐚𝐥 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡

Advancements in Teaching Computer-Aided Drug Design and Medicinal Chemistry: Strategies for Preparing Students Amidst Technological Evolution and Post-Pandemic Shifts.

January 14, 2026January 14, 2026 Selim

: Ajayi Titilope, Adewumi, Olanipekun Oladapo, Tunde, Esho Idowu, Johnson, Iyanda Dauda, Funminiyi.

📘 : Nexus Global Research Journal of Medical Sciences (NGRJMS) Volume-2, Issue-1 (Page : 20 – 24)

ABSTRACT:

The fields of medicinal chemistry and computer-aided drug design (CADD) have transformed due to technological progress, paradigm shifts in drug discovery, and the COVID-19 pandemic’s educational impact. This review synthesizes recent research to propose effective pedagogical strategies for higher education, exploring CADD’s historical evolution, post-pandemic student attitudes toward online learning, innovative open-source teaching platforms, and teacher perspectives on skill development. Challenges include bridging interdisciplinary gaps, overcoming online learning barriers, and preparing students for a dynamic industry. Recommendations advocate for hybrid models, hands-on tools, and ethical integration of emerging technologies like artificial intelligence (AI). Visual aids, including timelines, survey data, and tool comparisons, enhance understanding, equipping educators to foster future medicinal chemists ready to address global health challenges.

Keywords: Computer-aided drug design; Medicinal chemistry education; post-COVID learning; Open-source tools; Pedagogical strategies; Drug discovery paradigms.

Prevalence of Common Infectious Diseases Among Hospitalized Patients in Dera Ismail Khan, Khyber Pakhtunkhwa, Pakistan.

January 14, 2026January 14, 2026 Selim

: Abdus Sami, Saif Ullah Khan, Momna Elham.

🪪 : DOI: 10.5281/zenodo.18232684

📘 : Nexus Global Research Journal of Medical Sciences (NGRJMS) Volume-2, Issue-1 (Page : 05 – 10)

ABSTRACT:

Background: Worldwide, infectious agents cause a disproportionate share of illness and mortality. Using this data, researchers looked at the infectious illnesses and risk factors of Dera Ismail Khan hospital admissions. Method: Between January 2025 and November 2025, data from 840 individuals who visited four clinical laboratories in D. I. Khan were collected utilizing immune chromatographic technique. We acquired knowledge on the frequency and prevalence of each virus or illness. The research was conducted with the endorsement of the institutional ethics committee. The Top 5 list comprises the five most significant infectious agents and diseases. Result: Among the patients examined, 385 (45.83%) were infected with the Hepatitis B virus, 168 (20%) with Salmonella typhi (the causative agent of Typhoid fever), 128 (15.23%) with the Hepatitis C virus, 103 (12.26%) with Helicobacter pylori, and 56 (6.66%) with Plasmodium (the causative agent of malaria). A total of 840 individuals were tested for infectious diseases, with over half being male (443, or 52.73%). The remaining half comprised women (397, or 47.26%). The majority of cases involved individuals who were married (52.19%) and those aged between 21 and 30 years. Conclusion: This study facilitates the estimation of the prevalence of common illnesses, the evaluation of risk factors, and the management of these conditions in Pakistan.

Keywords: Infectious diseases, Disease prevalence, Hospitalized patients, Dera Ismail Khan, Khyber Pakhtunkhwa, Pakistan.

Management of Electrical Burn Injury of the Hand Using Collagen-Based Nanocrystalline Silver Cream: A Case Report.

January 14, 2026January 14, 2026 Selim

: Shubhra Mandal, Ravi Kumar Chittoria, Kanav Gupta.

🪪 : DOI: 10.5281/zenodo.18232751

📘 : Nexus Global Research Journal of Medical Sciences (NGRJMS) Volume-2, Issue-1 (Page : 01 – 04)

ABSTRACT:

Advances in the understanding of wound healing have encouraged the use of newer topical agents for managing both acute and chronic wounds. Silver-based preparations have traditionally formed an important component of burn care due to their antimicrobial properties. Nanocrystalline silver represents a refinement of conventional silver formulations by offering sustained antimicrobial activity along with modulation of the inflammatory response. Electrical burns affecting the hand present particular challenges because tissue injury is often unpredictable and infection risk is high. We report the conservative management of an elderly patient with an electrical burn injury to the hand using nanocrystalline silver cream, which resulte d in satisfactory wound healing without the need for surgical intervention.

Keywords: Electrical burn; Hand burn; Nanocrystalline silver; Burn wound management; Conservative treatment.

Impact of Entamoeba histolytica Infection on Liver Function: Analysis of AST, ALT, ALP, and Bilirubin Levels Among Patients at Al-Bayda Medical Center, Libya, 2025.

January 9, 2026January 9, 2026 Selim

: Nisreen Faraj Abdulai.

🪪 : DOI: 10.5281/zenodo.18186080

📘 : Nexus Global Research Journal of Medical Sciences (NGRJMS) Volume-1, Issue-1 (Page : 53 – 61)

ABSTRACT:

Entamoeba histolytica is a protozoan parasite causing amebiasis, which may involve the liver and lead to hepatocellular injury and biliary disturbances. This cross-sectional study evaluated the effect of E. histolytica infection on liver function among 50 patients attending Al-Bayda Medical Center, Libya, in 2025. Infection was determined using stool microscopy, with 30 patients testing positive and 20 negative. Serum liver function markers—alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (TB), and direct bilirubin (DB)—were analyzed using automated clinical chemistry systems. Normality was assessed with the Shapiro-Wilk test, and differences between groups were analyzed using the Wilcoxon rank-sum test, with effect sizes calculated to determine the magnitude of changes. Results showed significant elevations in ALT (47.2 ± 36.1 U/L vs. 12.4 ± 7.8 U/L; r = 0.804), AST (41.6 ± 16.2 U/L vs. 20.3 ± 10.2 U/L; r = 0.760), and ALP (144.0 ± 58.0 U/L vs. 88.2 ± 23.6 U/L; r = 0.550) in infected patients, indicating hepatocellular injury and possible cholestatic involvement. Total and direct bilirubin levels differed minimally, suggesting preserved bilirubin metabolism in most patients. These findings highlight the importance of monitoring liver function in patients with suspected or confirmed E. histolytica infection. Elevated hepatocellular enzymes may serve as early indicators of hepatic involvement, facilitating timely diagnosis and clinical management. This study provides insights into the biochemical impact of E. histolytica in a Libyan clinical setting and emphasizes the need for further research using imaging and molecular diagnostics for comprehensive hepatic assessment.

Keywords: Entamoeba histolytica; amebiasis; liver function tests; hepatocellular injury; Al-Bayda, Libya.

Regenerative Medicine: Advancements, Applications, and Future Perspectives.

December 14, 2025December 14, 2025 Selim

: Muhammad Akram, Mohammed Khudhair Hasan, Hind A. Abdulghafoor, Fahad Said Khan, Fethi Ahmet Ozdemir, Gaweł Sołowski, Jauher Bin Ali.

🪪 : DOI: 10.5281/zenodo.17905620

📘 : Nexus Global Research Journal of Medical Sciences (NGRJMS) Volume-1, Issue-1 (Page : 39 – 52)

ABSTRACT:

Regenerative medicine seeks to repair or replace damaged tissues and organs using cells, biomaterials, and molecular therapies. Key advances include stem cell therapies (e.g. induced pluripotent stem cells, ESCs, MSCs), precise gene editing (CRISPR/Cas9), and engineered tissues via 3D bioprinting. Artificial intelligence and big data are accelerating discovery in this field. Clinical trials report encouraging results: for example, patient-derived cells have improved retinal burns and heart function. Major applications are emerging in cardiology (heart repair), neurology (neuronal regeneration), and orthopedics (bone and cartilage repair). However, challenges remain, including immune rejection, tumor risk, and ethical concerns (embryo use, human cloning). Future directions point toward combining approaches: gene-edited universal donor tissues, vascularized organoids, and advanced bioreactors. As methods mature, regenerative medicine holds promise for chronic diseases and trauma. This review summarizes current breakthroughs, real-world implementations, ethical issues, and future prospects.

Keywords: Regenerative Medicine, Stem Cells, Crispr Gene Editing, 3d Bioprinting, Artificial Intelligence.

Awareness Of Hypertension And Target Organ Damage Among Hypertensives Aged 30 Years And Above In A Nigerian Out-patient Clinic

December 14, 2025December 14, 2025 Selim

: Nndunno Asheku Akwaras, Amindi Ntiense Iniodu, Tomen Ezekiel, Rose Obilom, Clement Amanyam, David Aondona Daniel.

🪪 : DOI: 10.5281/zenodo.17901765

📘 : Nexus Global Research Journal of Medical Sciences (NGRJMS) Volume-1, Issue-1 (Page : 20 – 38)

ABSTRACT:

Background: There is a growing prevalence of systemic hypertension mediated organ damage. This study assessed the awareness of hypertension and target organ damage (TOD) among hypertensives aged 30 years and above attending the outpatient clinic of Dalhatu Araf Specialist Hospital, Lafia, Nigeria. Methodology: This was a cross-sectional study. Systematic random sampling technique was used in selecting 261 respondents with systemic hypertension aged 30 years and above. Data was collected through interviewer administered questionnaire. They were screened for left ventricular hypertrophy, hypertensive retinopathy and kidney damage. Statistical package for Social Sciences version 23 was used to analyze the data. Statistical significance was set at p< 0.05 Results: The mean age of participants was 50.29 ± 12.73 years, with females making up 173 (66.3%) of the sample. Awareness of hypertension was 36.0% (94), while awareness of target organ damage was 42.1% (110). Hypertension had been diagnosed in 40.6% (106) of participants for less than five years. Additionally, 1.1% (3) smoked cigarettes, 2.3% (6) consumed significant amounts of alcohol, and 28.0% (73) were obese. The prevalence of microalbuminuria and target organ damage was 43.3% (113) and 77% (201), respectively. No significant association was found between awareness of hypertension and the presence of left ventricular hypertrophy, kidney damage, or retinopathy, indicating that awareness alone does not effectively reduce the occurrence of these complications.

Conclusion: Awareness of systemic hypertension and target organ damage is still low. There is urgent need for primary care physicians to raise awareness by increasing effort at giving proper education and counselling on the complications of systemic hypertension, importance of blood pressure control and adherence to treatment plan. This study can also serve as a basis for longitudinal studies on the relationship between awareness of systemic hypertension and development of target organ damage in patients with systemic hypertension.

Keywords: Awareness, hypertension, target organ damage, left ventricular hypertrophy, microalbuminuria, retinopathy

The Theatre Artiste and Medical Practitioner: The Need for MedicalComedy in Pediatric Clinic/Ward.

December 5, 2025December 5, 2025 Selim

: Chizenum George Ohia (PhD.)

🪪 : DOI: 10.5281/zenodo.17813021

📘 : Nexus Global Research Journal of Medical Sciences (NGRJMS) Vol- 1, Issue – 1 (2025) Page : 11 – 19

ABSTRACT:

Like security challenges, health management and care should not be the sole responsibility of medical practitioners alone but the collaboration of all and sundry. The need to incorporate the services of a theatre artiste in paediatric medicine should not be taken for granted. It is because encouraging comic theatrics and its attendant clown elements will facilitate smooth administration of care and healing in the paediatric ward. It is therefore the responsibility of a comedian (theatre artiste) to provide subtle jokes to divert the attention of a child from gazing at or rather being hostile to a doctor in the course of his or her duty. The use of comedy or medical clowns in paediatric clinics/wards lightens the hearts of both the medical doctor and the patients, thereby making the clinic exciting and allowing a free flow of medical attention. It is on the foregoing that this research deems it appropriate to seek synergy between the theatre artistes and medical practitioners in the provision and management of healthcare in the paediatric clinic/ward. This work employed analytical, literary, and socio-medical approaches. It also employed the relief theory of humour and Anna Freud’s theory of child psychology as critical pivots in the analysis of the topic under study. The work advocates for the interchange of ideas and synergy between the theatre artiste and medical doctor as a tool to enhance effective and efficient healthcare delivery in the paediatric clinic/ward.

Keywords: Theatre, Medicine, Artiste, Comedy, Paediatric Clinic/Ward, and Doctor

Seroprevalence of Hepatitis B Surface Antigen Positivity Among Antenatal Attendees in A Tertiary Hospital in Nigeria

December 5, 2025December 5, 2025 Selim

: Ihechinyerem Kelechi Osuagwu, Chioma Nwaonu Unachukwu, Charlotte Blanche Oguejiofor Chijioke, Ogomegbunam Ezeigwe, Malarchy Ekwunife Nwankwo, Chimezie Monica Eze, Chukwuemeka Jude Ofojebe, Chukwudi Anthony Ogabido, Onyecherelam Monday Ogelle, Ngozichukwu Gertrude Uzoewulu, Chukwuemeka Chidindu Njoku, Kingsley Chidiebere Nwaogu, Ifeanyichukwu Jude Ofor, Chidinma Theresa Ezidiegwu, William Amebeobari Mube, Agabus Iheanacho Nwachukwu, Stanley Chigaemezu Egbogu, Kesito Chikwendu Nwachukwu, Chukwunwendu Franklin Okeke, Nnaedozie Paul Obiegbu, Obinna Kenneth Nnabuchi, Chukwudi Anthony Ogabido, Johnbosco Emmanuel Mamah, George Uchenna Eleje.

🪪 : DOI: 10.5281/zenodo.17812342

📘 : Nexus Global Research Journal of Medical Sciences (NGRJMS) Vol – 1, Issue 1 (2025), PP: 01-10

ABSTRACT:

BACKGROUND: Hepatitis B virus infection is a public health problem in our environment. Vertical transmission from mother to baby is an important route of transmission of the virus. Neonates who contact hepatitis B have an almost 90% risk of developing chronic HBsAg carriage and chronic liver disease. Neonatal immunization interrupts this carriage. Adult immunization and treatment reduce the transmissibility and the viral burden. AIMS: The study is aimed to determine the prevalence of Hepatitis B surface antigen positivity and possible associated risk factors to the spread of the virus among antenatal attendee. METHODS: A cross sectional study was conducted among 158 pregnant women attending the antenatal clinics of the Federal Medical Centre, Owerri, Nigeria. Serum was extracted from venous blood collected from each subject and tested for the presence of HBsAg using one step HBsAg test strip. A pre-structured questionnaire was used to collect sociodemographic data as well as to ascertain possible risk factors. A p-value less than 0.05 was considered as statistically significant association. RESULTS: Fifteen out of one hundred and fifty-eight women were seropositive for HBsAg giving a seroprevalence rate of 9.5%. The seroprevalence of HBsAg increased significantly with increasing age of the patients. There were significant associations between the disease and the patient’s occupations, occupations related to needlework, past history of traditional surgery amongst others. There were no significant associations between Hepatitis B surface antigen seroprevalence and religion of the patients’, educational level, past history of jaundice or liver disease amongst others. CONCLUSION: The seroprevalence of HBsAg in the study was high. This reinforces the need for routine antenatal screening for HBsAg, routine neonatal passive immunization for neonates of HBsAg positive mothers and active immunization for all