The Role of Medical Libraries in Supporting Evidence – Based Practice among Health Professionals

April 18, 2026April 18, 2026 Selim

The Role of Medical Libraries in Supporting Evidence – Based Practice among Health Professionals

📘 : Nexus Global Research Journal of Medical Sciences (NGRJMS) Volume 2, Issue 2, 2026 (Page : 48 – 56)

ABSTRACT:

Evidence-Based Practice (EBP) has become a foundational approach in modern healthcare delivery, emphasizing the use of current, valid, and clinically relevant evidence in decision-making. Health professionals including physicians, nurses, pharmacists, laboratory scientists, physiotherapists, and public health practitioners depend on timely access to credible medical information to ensure accurate diagnosis, safe treatment decisions, and improved patient outcomes. Medical libraries, whether situated in teaching hospitals, medical schools, research institutes, or specialized healthcare facilities, serve as critical infrastructures for promoting and sustaining evidence-based healthcare practice. They provide access to scholarly databases, peer-reviewed journals, clinical guidelines, and systematic reviews, while also offering professional support through literature searching, information literacy training, research assistance, and knowledge management services. This paper examines the role of medical libraries in supporting evidence-based practice among health professionals. It explores key concepts of EBP, highlights the functions of medical libraries in facilitating evidence access and utilization, and discusses challenges limiting library support for EBP such as inadequate funding, limited digital infrastructure, poor awareness, and shortage of trained medical librarians. The paper also provides recommendations for strengthening medical library services through capacity building, digital transformation, collaborative partnerships, and policy support. The study concludes that medical libraries are indispensable partners in healthcare delivery and play an essential role in improving clinical outcomes by empowering health professionals with evidence-based information resources and services.

Keywords: Medical libraries, Evidence-based practice, Health professionals, Knowledge management, Health information services.

Calcitonin-Augmented Epidural Steroid Injection for Lumbar Canal Stenosis: A Randomized Controlled Study

April 14, 2026April 14, 2026 Selim

Calcitonin-Augmented Epidural Steroid Injection for Lumbar Canal Stenosis: A Randomized Controlled Study

: Hossam Saad.

🪪 : DOI: 10.5281/zenodo.18241187

📘 : Nexus Global Research Journal of Medical Sciences (NGRJMS) Volume 2, Issue 1, 2026 (Page : 11 – 19)

ABSTRACT:

Background: Lumbar spinal canal stenosis (LSS) causes back and leg pain. Epidural steroid injection (ESI) provides shortterm relief in many patients. Calcitonin has analgesic properties and may augment ESI effects. Objective: To evaluate whether adding calcitonin to epidural steroid injection improves pain and function compared with steroid alone in symptomatic LSS. Methods: Prospective, randomized, double-blind trial. 73 patients/group (total n=146) with MRI-confirmed LSS received either methylprednisolone 40 mg + lidocaine 0.5% + saline (Group A) or methylprednisolone 40 mg + lidocaine 0.5% + calcitonin 50 IU (Group B). Two injections 1 week apart. Follow-up at 2 weeks, 1, 2, 3 (primary), 6 and 12 months. Primary outcome: change in VAS at 3 months. Results: At 3 months VAS decreased from 7.2±1.0 to 4.8±1.5 in Group A and to 3.1±1.4 in Group B (between-group p<0.001). ODI improved from 52±9% to 36±9% in Group A and to 28±8% in Group B (p=0.002). Walking distance increased from 150±60 m to 310±90 m (Group A) and to 430±110 m (Group B) at 3 months (p<0.001). Adverse events were mild: nausea (Group A 2/73, 2.7%; Group B 6/73, 8.2%). Conclusion: Calcitonin-augmented ESI provides superior pain relief and functional outcomes compared with steroid alone. Larger multicenter trials are recommended.

Keywords: Vitamin D; Frozen Embryo Transfer; Infertility; Clinical Pregnancy; Live Birth Rate; Meta-analysis

Role of Dermabrasion Assisted Tangential Excision and Grafting inPerineal Burns

April 14, 2026April 14, 2026 Selim

Role of Dermabrasion Assisted Tangential Excision and Grafting inPerineal Burns

: Siddharth Ravi, Ravi Kumar Chittoria, Kanav Gupta, Srinath Rajasekar

🪪 : DOI: 10.5281/zenodo.18340047

📘 : Nexus Global Research Journal of Medical Sciences (NGRJMS) Volume 2, Issue 1, 2026 (Page : 25 – 28)

ABSTRACT:

Burn wound management requires early and effective removal of devitalized tissue to promote healing, prevent infection, and improve functional and cosmetic outcomes. Dermabrasion, a mechanical method of controlled superficial tissue removal, is a well-established technique in plastic surgery but remains relatively underutilized in burn care. This article evaluates the role of dermabrasion-assisted tangential excision followed by grafting in the management of scald burns, particularly in challenging anatomical regions. We present a clinical case of a 2-year-old female with 15% total body surface area superficial and deep second-degree scald burns over the gluteal region. The patient underwent dermabrasion-assisted tangential excision using a high-speed dermabrader, followed by full-thickness skin allografting. The intervention resulted in early wound coverage, satisfactory graft takes, reduced risk of infection, accelerated healing, shorter hospital stays, and good patient compliance.

Keywords: Dermabrasion-assisted excision; Scald burns; Pediatric burn management; Tangential excision; Skin allografting; Early wound healing

Biochemical Profile of Renal Dysfunction in Type 2 Diabetes Mellitus: Insights from a Libyan Case-Control Study

April 14, 2026April 14, 2026 Selim

Biochemical Profile of Renal Dysfunction in Type 2 Diabetes Mellitus: Insights from a Libyan Case-Control Study

: Hossam B. Bahnasy

🪪 : DOI: 10.5281/zenodo.18940929

📘 : Nexus Global Research Journal of Medical Sciences (NGRJMS) Volume 2, Issue 2, 2026 (Page : 29 – 33)

ABSTRACT:

Diabetes mellitus significantly elevates the risk of renal impairment, characterized by abnormal levels of serum creatinine, urea, and other electrolytes. In this case-control study, we compared 84 type 2 diabetes mellitus (T2DM) patients (cases) with 20 healthy controls, finding 100% prevalence of abnormal blood urea and creatinine in cases versus none in controls (p<0.001) (1). Key correlations included positive associations between creatinine and HbA1c (rs=0.303, p=0.005), random blood sugar (RBS; rs=0.269, p=0.013), and serum phosphorus (rs=0.325, p=0.003). These findings underscore hyperglycemia’s role in diabetic kidney disease (DKD) progression, aligning with recent evidence on modifiable risk factors like poor glycemic control. Early biochemical screening is recommended for 2DM management to prevent end-stage renal disease (2,3). This study analyzes biochemical data from 84 diabetic patients and 20 controls, revealing strong associations between diabetes and renal dysfunction markers like elevated creatinine and urea (4,5,6).

Keywords: Diabetes, Renal dysfunction, and Biochemical markers, Glycated Hemoglobin

Impact of Urbanization on Public Health

April 14, 2026April 14, 2026 Selim

Impact of Urbanization on Public Health

: Peter F. Lang

🪪 : DOI: 10.5281/zenodo.18924773

📘 : Nexus Global Research Journal of Medical Sciences (NGRJMS) Volume 2, Issue 2, 2026 (Page : 34 – 40)

ABSTRACT:

This work shows the consequence of increased urbanization on the impact of pandemics and infectious diseases on public health especially in inner city areas. It demonstrates that the Covid-19 pandemic impacts particularly on large cities and urban areas. There have been many pandemics throughout history and they occurred mainly in cities. Mortality rates show vaccines are not 100% effective against all variants. The trend in increasing urbanization enhances the probability of more serious pandemics in the future with disparity against lower income inhabitants in inner cities. This work discusses ways which public health can be improved.

Keywords: Urbanization, Infection, Public Health. Pandemic

A Prospective Observational Study of Coagulation Profiles in Patients on Common Antithrombotic Therapies and Their Correlation with Bleeding Risk

April 14, 2026April 14, 2026 Selim

A Prospective Observational Study of Coagulation Profiles in Patients on Common Antithrombotic Therapies and Their Correlation with Bleeding Risk

: Ogonnaya Chinemerem Cynthia, Verla Evelyn Ngozi, Ugwulor Louis Oguchukwu, Verla Andrew Wirnkor, Achang Keneth Youngabi.

🪪 : DOI: 10.5281/zenodo.19044290

📘 : Nexus Global Research Journal of Medical Sciences (NGRJMS) Volume 2, Issue 2, 2026 (Page : 41 – 47)

ABSTRACT:

Antithrombotic therapies including warfarin and antiplatelet agents require careful monitoring to balance thrombotic protection against bleeding risk. This is particularly challenging in resource-limited settings where access to specialized coagulation testing is often restricted. A prospective observational study was conducted from January to December 2023 at three tertiary care hospitals in Nigeria. We enrolled 450 patients on stable antithrombotic therapy (150 on warfarin, 150 on aspirin, 150 on clopidogrel) and followed them for six months. Prothrombin time/international normalized ratio (PT/INR), activated partial thromboplastin time (aPTT), and bleeding events were monitored monthly. Among warfarin patients, only 42.7% maintained therapeutic INR ranges (2.0-3.0) across all measurements, while 34.0% showed subtherapeutic and 23.3% supratherapeutic values. The incidence of major bleeding was significantly higher in patients with INR >3.5 (18.9% vs. 2.3% in therapeutic range, p<0.001). Antiplatelet therapy patients demonstrated minimal changes in conventional coagulation parameters despite clinically significant bleeding events. Multivariate analysis identified age >65 years (OR: 3.2, 95% CI: 1.8-5.7), renal impairment (OR: 2.8, 95% CI: 1.5-5.2), and concomitant NSAID use (OR: 2.4, 95% CI: 1.3-4.4) as independent predictors of bleeding Basic coagulation tests effectively stratify bleeding risk in warfarin-treated patients but have limited utility for monitoring antiplatelet therapies. Simplified risk assessment tools incorporating clinical factors and basic laboratory parameters can optimize antithrombotic management in settings with limited resources.

Keywords: Antithrombotic, Antiplatelet agents, Bleeding risk, Coagulation profiles, INR monitoring, Resource-limited settings, Warfarin

Advancements in Teaching Computer-Aided Drug Design and Medicinal Chemistry: Strategies for Preparing Students Amidst Technological Evolution and Post-Pandemic Shifts.

January 14, 2026April 7, 2026 Selim

Advancements in Teaching Computer-Aided Drug Design and Medicinal Chemistry: Strategies for Preparing Students Amidst Technological Evolution and Post-Pandemic Shifts.

: Ajayi Titilope, Adewumi, Olanipekun Oladapo, Tunde, Esho Idowu, Johnson, Iyanda Dauda, Funminiyi.

🪪 : DOI: 10.5281/zenodo.18242699

📘 : Nexus Global Research Journal of Medical Sciences (NGRJMS) Volume-2, Issue-1 (Page : 20 – 24)

ABSTRACT:

The fields of medicinal chemistry and computer-aided drug design (CADD) have transformed due to technological progress, paradigm shifts in drug discovery, and the COVID-19 pandemic’s educational impact. This review synthesizes recent research to propose effective pedagogical strategies for higher education, exploring CADD’s historical evolution, post-pandemic student attitudes toward online learning, innovative open-source teaching platforms, and teacher perspectives on skill development. Challenges include bridging interdisciplinary gaps, overcoming online learning barriers, and preparing students for a dynamic industry. Recommendations advocate for hybrid models, hands-on tools, and ethical integration of emerging technologies like artificial intelligence (AI). Visual aids, including timelines, survey data, and tool comparisons, enhance understanding, equipping educators to foster future medicinal chemists ready to address global health challenges.

Keywords: Computer-aided drug design; Medicinal chemistry education; post-COVID learning; Open-source tools; Pedagogical strategies; Drug discovery paradigms.

Prevalence of Common Infectious Diseases Among Hospitalized Patients in Dera Ismail Khan, Khyber Pakhtunkhwa, Pakistan.

January 14, 2026April 7, 2026 Selim

Prevalence of Common Infectious Diseases Among Hospitalized Patients in Dera Ismail Khan, Khyber Pakhtunkhwa, Pakistan.

: Abdus Sami, Saif Ullah Khan, Momna Elham.

🪪 : DOI: 10.5281/zenodo.18232684

📘 : Nexus Global Research Journal of Medical Sciences (NGRJMS) Volume-2, Issue-1 (Page : 05 – 10)

ABSTRACT:

Background: Worldwide, infectious agents cause a disproportionate share of illness and mortality. Using this data, researchers looked at the infectious illnesses and risk factors of Dera Ismail Khan hospital admissions. Method: Between January 2025 and November 2025, data from 840 individuals who visited four clinical laboratories in D. I. Khan were collected utilizing immune chromatographic technique. We acquired knowledge on the frequency and prevalence of each virus or illness. The research was conducted with the endorsement of the institutional ethics committee. The Top 5 list comprises the five most significant infectious agents and diseases. Result: Among the patients examined, 385 (45.83%) were infected with the Hepatitis B virus, 168 (20%) with Salmonella typhi (the causative agent of Typhoid fever), 128 (15.23%) with the Hepatitis C virus, 103 (12.26%) with Helicobacter pylori, and 56 (6.66%) with Plasmodium (the causative agent of malaria). A total of 840 individuals were tested for infectious diseases, with over half being male (443, or 52.73%). The remaining half comprised women (397, or 47.26%). The majority of cases involved individuals who were married (52.19%) and those aged between 21 and 30 years. Conclusion: This study facilitates the estimation of the prevalence of common illnesses, the evaluation of risk factors, and the management of these conditions in Pakistan.

Keywords: Infectious diseases, Disease prevalence, Hospitalized patients, Dera Ismail Khan, Khyber Pakhtunkhwa, Pakistan.

Management of Electrical Burn Injury of the Hand Using Collagen-Based Nanocrystalline Silver Cream: A Case Report.

January 14, 2026April 7, 2026 Selim

Management of Electrical Burn Injury of the Hand Using Collagen-Based Nanocrystalline Silver Cream: A Case Report.

: Shubhra Mandal, Ravi Kumar Chittoria, Kanav Gupta.

🪪 : DOI: 10.5281/zenodo.18232751

📘 : Nexus Global Research Journal of Medical Sciences (NGRJMS) Volume-2, Issue-1 (Page : 01 – 04)

ABSTRACT:

Advances in the understanding of wound healing have encouraged the use of newer topical agents for managing both acute and chronic wounds. Silver-based preparations have traditionally formed an important component of burn care due to their antimicrobial properties. Nanocrystalline silver represents a refinement of conventional silver formulations by offering sustained antimicrobial activity along with modulation of the inflammatory response. Electrical burns affecting the hand present particular challenges because tissue injury is often unpredictable and infection risk is high. We report the conservative management of an elderly patient with an electrical burn injury to the hand using nanocrystalline silver cream, which resulte d in satisfactory wound healing without the need for surgical intervention.

Keywords: Electrical burn; Hand burn; Nanocrystalline silver; Burn wound management; Conservative treatment.

Impact of Entamoeba histolytica Infection on Liver Function: Analysis of AST, ALT, ALP, and Bilirubin Levels Among Patients at Al-Bayda Medical Center, Libya, 2025.

January 9, 2026April 7, 2026 Selim

Impact of Entamoeba histolytica Infection on Liver Function: Analysis of AST, ALT, ALP, and Bilirubin Levels Among Patients at Al-Bayda Medical Center, Libya, 2025.

: Nisreen Faraj Abdulai.

🪪 : DOI: 10.5281/zenodo.18186080

📘 : Nexus Global Research Journal of Medical Sciences (NGRJMS) Volume-1, Issue-1 (Page : 53 – 61)

ABSTRACT:

Entamoeba histolytica is a protozoan parasite causing amebiasis, which may involve the liver and lead to hepatocellular injury and biliary disturbances. This cross-sectional study evaluated the effect of E. histolytica infection on liver function among 50 patients attending Al-Bayda Medical Center, Libya, in 2025. Infection was determined using stool microscopy, with 30 patients testing positive and 20 negative. Serum liver function markers—alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (TB), and direct bilirubin (DB)—were analyzed using automated clinical chemistry systems. Normality was assessed with the Shapiro-Wilk test, and differences between groups were analyzed using the Wilcoxon rank-sum test, with effect sizes calculated to determine the magnitude of changes. Results showed significant elevations in ALT (47.2 ± 36.1 U/L vs. 12.4 ± 7.8 U/L; r = 0.804), AST (41.6 ± 16.2 U/L vs. 20.3 ± 10.2 U/L; r = 0.760), and ALP (144.0 ± 58.0 U/L vs. 88.2 ± 23.6 U/L; r = 0.550) in infected patients, indicating hepatocellular injury and possible cholestatic involvement. Total and direct bilirubin levels differed minimally, suggesting preserved bilirubin metabolism in most patients. These findings highlight the importance of monitoring liver function in patients with suspected or confirmed E. histolytica infection. Elevated hepatocellular enzymes may serve as early indicators of hepatic involvement, facilitating timely diagnosis and clinical management. This study provides insights into the biochemical impact of E. histolytica in a Libyan clinical setting and emphasizes the need for further research using imaging and molecular diagnostics for comprehensive hepatic assessment.

Keywords: Entamoeba histolytica; amebiasis; liver function tests; hepatocellular injury; Al-Bayda, Libya.