: Muhammad Akram, Mohammed Khudhair Hasan, Hind A. Abdulghafoor, Fahad Said Khan, Fethi Ahmet Ozdemir, Gaweล Soลowski, Jauher Bin Ali.๐ชช : DOI:ย ย 10.5281/zenodo.17905620
๐ : Nexus Global Research Journal of Medical Sciences (NGRJMS) Volume-1, Issue-1 (Page : 39 – 52)
ABSTRACT:
Regenerative medicine seeks to repair or replace damaged tissues and organs using cells, biomaterials, and molecular therapies. Key advances include stem cell therapies (e.g. induced pluripotent stem cells, ESCs, MSCs), precise gene editing (CRISPR/Cas9), and engineered tissues via 3D bioprinting. Artificial intelligence and big data are accelerating discovery in this field. Clinical trials report encouraging results: for example, patient-derived cells have improved retinal burns and heart function. Major applications are emerging in cardiology (heart repair), neurology (neuronal regeneration), and orthopedics (bone and cartilage repair). However, challenges remain, including immune rejection, tumor risk, and ethical concerns (embryo use, human cloning). Future directions point toward combining approaches: gene-edited universal donor tissues, vascularized organoids, and advanced bioreactors. As methods mature, regenerative medicine holds promise for chronic diseases and trauma. This review summarizes current breakthroughs, real-world implementations, ethical issues, and future prospects.
Keywords: Regenerative Medicine, Stem Cells, Crispr Gene Editing, 3d Bioprinting, Artificial Intelligence.