Regenerative Medicine: Advancements, Applications, and Future Perspectives.

December 14, 2025April 7, 2026 Selim

Regenerative Medicine: Advancements, Applications, and Future Perspectives.

: Muhammad Akram, Mohammed Khudhair Hasan, Hind A. Abdulghafoor, Fahad Said Khan, Fethi Ahmet Ozdemir, Gaweł Sołowski, Jauher Bin Ali.

🪪 : DOI: 10.5281/zenodo.17905620

📘 : Nexus Global Research Journal of Medical Sciences (NGRJMS) Volume-1, Issue-1 (Page : 39 – 52)

ABSTRACT:

Regenerative medicine seeks to repair or replace damaged tissues and organs using cells, biomaterials, and molecular therapies. Key advances include stem cell therapies (e.g. induced pluripotent stem cells, ESCs, MSCs), precise gene editing (CRISPR/Cas9), and engineered tissues via 3D bioprinting. Artificial intelligence and big data are accelerating discovery in this field. Clinical trials report encouraging results: for example, patient-derived cells have improved retinal burns and heart function. Major applications are emerging in cardiology (heart repair), neurology (neuronal regeneration), and orthopedics (bone and cartilage repair). However, challenges remain, including immune rejection, tumor risk, and ethical concerns (embryo use, human cloning). Future directions point toward combining approaches: gene-edited universal donor tissues, vascularized organoids, and advanced bioreactors. As methods mature, regenerative medicine holds promise for chronic diseases and trauma. This review summarizes current breakthroughs, real-world implementations, ethical issues, and future prospects.

Keywords: Regenerative Medicine, Stem Cells, Crispr Gene Editing, 3d Bioprinting, Artificial Intelligence.

Awareness Of Hypertension And Target Organ Damage Among Hypertensives Aged 30 Years And Above In A Nigerian Out-patient Clinic

December 14, 2025April 7, 2026 Selim

Awareness Of Hypertension And Target Organ Damage Among Hypertensives Aged 30 Years And Above In A Nigerian Out-patient Clinic

: Nndunno Asheku Akwaras, Amindi Ntiense Iniodu, Tomen Ezekiel, Rose Obilom, Clement Amanyam, David Aondona Daniel.

🪪 : DOI: 10.5281/zenodo.17901765

📘 : Nexus Global Research Journal of Medical Sciences (NGRJMS) Volume-1, Issue-1 (Page : 20 – 38)

ABSTRACT:

Background: There is a growing prevalence of systemic hypertension mediated organ damage. This study assessed the awareness of hypertension and target organ damage (TOD) among hypertensives aged 30 years and above attending the outpatient clinic of Dalhatu Araf Specialist Hospital, Lafia, Nigeria. Methodology: This was a cross-sectional study. Systematic random sampling technique was used in selecting 261 respondents with systemic hypertension aged 30 years and above. Data was collected through interviewer administered questionnaire. They were screened for left ventricular hypertrophy, hypertensive retinopathy and kidney damage. Statistical package for Social Sciences version 23 was used to analyze the data. Statistical significance was set at p< 0.05 Results: The mean age of participants was 50.29 ± 12.73 years, with females making up 173 (66.3%) of the sample. Awareness of hypertension was 36.0% (94), while awareness of target organ damage was 42.1% (110). Hypertension had been diagnosed in 40.6% (106) of participants for less than five years. Additionally, 1.1% (3) smoked cigarettes, 2.3% (6) consumed significant amounts of alcohol, and 28.0% (73) were obese. The prevalence of microalbuminuria and target organ damage was 43.3% (113) and 77% (201), respectively. No significant association was found between awareness of hypertension and the presence of left ventricular hypertrophy, kidney damage, or retinopathy, indicating that awareness alone does not effectively reduce the occurrence of these complications.

Conclusion: Awareness of systemic hypertension and target organ damage is still low. There is urgent need for primary care physicians to raise awareness by increasing effort at giving proper education and counselling on the complications of systemic hypertension, importance of blood pressure control and adherence to treatment plan. This study can also serve as a basis for longitudinal studies on the relationship between awareness of systemic hypertension and development of target organ damage in patients with systemic hypertension.

Keywords: Awareness, hypertension, target organ damage, left ventricular hypertrophy, microalbuminuria, retinopathy

The Theatre Artiste and Medical Practitioner: The Need for Medical Comedy in Pediatric Clinic/Ward.

December 5, 2025April 14, 2026 Selim

The Theatre Artiste and Medical Practitioner: The Need for Medical Comedy in Pediatric Clinic/Ward.

: Chizenum George Ohia (PhD.)

🪪 : DOI: 10.5281/zenodo.17813021

📘 : Nexus Global Research Journal of Medical Sciences (NGRJMS) Vol- 1, Issue – 1 (2025) Page : 11 – 19

ABSTRACT:

Like security challenges, health management and care should not be the sole responsibility of medical practitioners alone but the collaboration of all and sundry. The need to incorporate the services of a theatre artiste in paediatric medicine should not be taken for granted. It is because encouraging comic theatrics and its attendant clown elements will facilitate smooth administration of care and healing in the paediatric ward. It is therefore the responsibility of a comedian (theatre artiste) to provide subtle jokes to divert the attention of a child from gazing at or rather being hostile to a doctor in the course of his or her duty. The use of comedy or medical clowns in paediatric clinics/wards lightens the hearts of both the medical doctor and the patients, thereby making the clinic exciting and allowing a free flow of medical attention. It is on the foregoing that this research deems it appropriate to seek synergy between the theatre artistes and medical practitioners in the provision and management of healthcare in the paediatric clinic/ward. This work employed analytical, literary, and socio-medical approaches. It also employed the relief theory of humour and Anna Freud’s theory of child psychology as critical pivots in the analysis of the topic under study. The work advocates for the interchange of ideas and synergy between the theatre artiste and medical doctor as a tool to enhance effective and efficient healthcare delivery in the paediatric clinic/ward.

Keywords: Theatre, Medicine, Artiste, Comedy, Paediatric Clinic/Ward, and Doctor

Seroprevalence of Hepatitis B Surface Antigen Positivity Among Antenatal Attendees in A Tertiary Hospital in Nigeria

December 5, 2025April 14, 2026 Selim

Seroprevalence of Hepatitis B Surface Antigen Positivity Among Antenatal Attendees in A Tertiary Hospital in Nigeria

: Ihechinyerem Kelechi Osuagwu, Chioma Nwaonu Unachukwu, Charlotte Blanche Oguejiofor Chijioke, Ogomegbunam Ezeigwe, Malarchy Ekwunife Nwankwo, Chimezie Monica Eze, Chukwuemeka Jude Ofojebe, Chukwudi Anthony Ogabido, Onyecherelam Monday Ogelle, Ngozichukwu Gertrude Uzoewulu, Chukwuemeka Chidindu Njoku, Kingsley Chidiebere Nwaogu, Ifeanyichukwu Jude Ofor, Chidinma Theresa Ezidiegwu, William Amebeobari Mube, Agabus Iheanacho Nwachukwu, Stanley Chigaemezu Egbogu, Kesito Chikwendu Nwachukwu, Chukwunwendu Franklin Okeke, Nnaedozie Paul Obiegbu, Obinna Kenneth Nnabuchi, Chukwudi Anthony Ogabido, Johnbosco Emmanuel Mamah, George Uchenna Eleje.

🪪 : DOI: 10.5281/zenodo.17812342

📘 : Nexus Global Research Journal of Medical Sciences (NGRJMS) Vol – 1, Issue 1 (2025), PP: 01-10

ABSTRACT:

BACKGROUND: Hepatitis B virus infection is a public health problem in our environment. Vertical transmission from mother to baby is an important route of transmission of the virus. Neonates who contact hepatitis B have an almost 90% risk of developing chronic HBsAg carriage and chronic liver disease. Neonatal immunization interrupts this carriage. Adult immunization and treatment reduce the transmissibility and the viral burden. AIMS: The study is aimed to determine the prevalence of Hepatitis B surface antigen positivity and possible associated risk factors to the spread of the virus among antenatal attendee. METHODS: A cross sectional study was conducted among 158 pregnant women attending the antenatal clinics of the Federal Medical Centre, Owerri, Nigeria. Serum was extracted from venous blood collected from each subject and tested for the presence of HBsAg using one step HBsAg test strip. A pre-structured questionnaire was used to collect sociodemographic data as well as to ascertain possible risk factors. A p-value less than 0.05 was considered as statistically significant association. RESULTS: Fifteen out of one hundred and fifty-eight women were seropositive for HBsAg giving a seroprevalence rate of 9.5%. The seroprevalence of HBsAg increased significantly with increasing age of the patients. There were significant associations between the disease and the patient’s occupations, occupations related to needlework, past history of traditional surgery amongst others. There were no significant associations between Hepatitis B surface antigen seroprevalence and religion of the patients’, educational level, past history of jaundice or liver disease amongst others. CONCLUSION: The seroprevalence of HBsAg in the study was high. This reinforces the need for routine antenatal screening for HBsAg, routine neonatal passive immunization for neonates of HBsAg positive mothers and active immunization for all